LDN

Rx Only

Oral Capsule

When inflammation, discomfort, or fatigue keeps getting in the way, LDN works with the body’s opioid and immune signaling systems to support greater balance and everyday resilience.

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WHATS INCLUDED

Licensed provider evaluation
Ongoing treatment review and provider support
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What is

LDN

Low dose naltrexone, or LDN, uses naltrexone at a much lower dose than its standard approved uses. Naltrexone blocks opioid receptors temporarily, which may influence the body’s natural endorphin production and immune signaling. This makes LDN especially relevant for people seeking support with persistent discomfort, inflammatory balance, fatigue, and overall resilience.

Your treatment is part of a broader care plan, with licensed provider oversight, ongoing support, and guidance as your needs and goals change over time.

Your compound is prepared at a licensed 503A pharmacy, meaning it's made specifically for you under a valid prescription, and every batch is third-party tested for purity and potency before it reaches your door.

LDN

Benefits

How Low Dose Naltrexone Works

Low dose naltrexone, or LDN, temporarily interacts with opioid receptors involved in pain perception, endorphin activity, and immune signaling. At lower doses, it is used to support a more balanced response to discomfort and inflammation. Naltrexone is an opioid receptor antagonist.

Support for Inflammatory Balance

LDN may help regulate immune signals involved in the body’s inflammatory response.

Greater Everyday Comfort

By influencing pathways connected to pain perception, LDN may support greater comfort and easier daily movement.

Support for Energy and Resilience

When ongoing discomfort or inflammatory stress is reduced, people may feel better able to manage daily physical and mental demands.

Support for Natural Endorphin Activity

Its temporary effect on opioid receptors may influence the body’s own endorphin signaling, which is connected to comfort and well-being.

Your Ongoing Care

Your treatment is provider-guided from the start and can be adjusted based on how you respond and tolerate each dose. Ongoing reviews give your provider a chance to understand what you’re noticing, address side effects, and determine whether your treatment plan should stay the same or change. Your care team is available throughout treatment whenever questions or concerns come up.

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Professionals you can count on every step of the way

Dr. ERIK STARK

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Dr. Erik Stark is a board-certified orthopedic and sports medicine surgeon with expertise in obesity and longevity medicine. A lifelong athlete and jiu-jitsu black belt, he combines clinical expertise with a performance-focused approach to helping patients stay strong, active, and healthy.

ELISA GEORGE

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Elisa George is CEO of Everprime and a brand, growth, and business executive with 18 years of experience building and scaling consumer businesses. She brings deep expertise in brand strategy, product development, growth, and consumer experience, with a particular passion for women’s health, wellness, and longevity.

Dr. VISHAL VERMA

Clinical Advisor

Dr. Vishal Verma is Executive Chairman of EverPrime and a physician, healthcare executive, and serial entrepreneur. With decades of experience building and leading healthcare companies, he brings deep expertise in healthcare innovation, technology, longevity, and wellness.

MEDICAL DIRECTOR

Dr. ERIK STARK

Medical Director

OPERATIONAL DIRECTOR

ELISA GEORGE

CEO

CLINICAL ADVISOR

Dr. VISHAL VERMA

Clinical Advisor

HAVE QUESTIONS?

What is LDN (Low Dose Naltrexone), and how does it work?

LDN stands for Low Dose Naltrexone, a prescription medication taken at a fraction of its standard dose to produce a completely different and remarkable set of effects. At very low doses, LDN briefly and gently blocks your opioid receptors for just a few hours, which triggers your body to respond by producing a surge of its own natural endorphins and immune-regulating compounds. This rebound effect recalibrates your immune system, reduces chronic inflammation, and supports your body's natural pain management pathways. It's typically taken as a small oral capsule at bedtime, and because it works with your body's own systems rather than overriding them, it's considered very safe and well-tolerated under medical supervision.

What conditions is LDN used for at EverPrime?

Low-dose naltrexone (LDN) may be considered for patients experiencing symptoms related to certain autoimmune conditions, chronic pain, inflammation, or persistent fatigue. LDN is used off-label for these purposes, meaning these uses have not been specifically approved by the FDA. Research is still evolving, and the evidence supporting LDN varies by condition. Your provider will review your symptoms, health history, and treatment goals to determine whether LDN may be appropriate for you and discuss what you can realistically expect from treatment.

When is the best time to take LDN?

LDN is often taken at bedtime because its effects may support the body’s natural overnight endorphin activity. Since LDN has a relatively short half-life, about 4 hours, its temporary receptor-blocking effects typically wear off by morning. However, bedtime dosing isn’t right for everyone. If LDN affects your sleep or how you feel during the day, your provider may recommend adjusting the timing to better fit your needs and daily routin

How quickly will I notice LDN working?

Most patients begin to notice meaningful changes within 4 to 12 weeks. Early signs that it's working include improved sleep quality, a softening of chronic pain or stiffness, more stable energy, and subtle mood improvements.

How do you monitor LDN treatment for long-term safety and effectiveness?

Your LDN treatment is monitored over time to make sure it remains both safe and effective for you. Your provider may review your symptoms, overall health, medication use, and, when appropriate, lab results as part of your ongoing care. We also screen carefully for medications that may not be compatible with LDN, particularly opioid medications. Your treatment plan can be adjusted based on how you respond, any side effects you experience, and changes in your health or medications.

Are there side effects, and what should I expect in the first few weeks?

The most commonly reported early side effect is vivid or unusual dreams during the first one to two weeks, which typically resolves on its own as your body adjusts. Some patients experience a brief, temporary flare of their symptoms in the first week, this is actually a sign that the immune system is responding and recalibrating, not a sign that something is wrong. Your EverPrime provider will guide you through the adjustment period and can make small dose tweaks if needed.

How might LDN influence mood and cognitive function beyond its immunological benefits?

By elevating endogenous opioids, LDN can enhance neurochemical pathways involved in mood regulation, stress resilience, and cognitive clarity. Patients frequently report reduced anxiety, enhanced mental focus, and improved emotional stability.

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