Rx Only

Availability varies by state. This treatment isn't offered in every state. Your intake will confirm what's available where you live and recommend the best option for you.

GLP-1 + GIP Semaglutide + Tirzepatide

Injection

Stalled on a single GLP-1? This combines semaglutide and tirzepatide to work across three receptor targets at once. It’s a stronger, broader approach built to push past stubborn plateaus, with dosing and side effects monitored closely.

Same Pricing - All Doses

Delivery of Medication Every 4 Weeks

Ongoing Provider Care & Support

Free Shipping

Thank you! Your submission has been received!

Oops! Something went wrong while submitting the form.

Thank you! Your submission has been received!

Oops! Something went wrong while submitting the form.

Select Package:

WHATS INCLUDED

Video visit every 90 days

Metabolic lab testing every 6 months

Injection Supplies (Syringes, Needles & Alcohol Swabs)

Free Shipping

What is

GLP-1 + GIP Semaglutide + Tirzepatide

This compound combines semaglutide and tirzepatide, engaging your body's GLP-1 receptors from two complementary angles while also activating GIP receptors through tirzepatide's dual action. This broader receptor coverage means appetite signaling, digestion, and insulin and glucagon regulation are all addressed more fully than with a single-agent approach, which is why it's often recommended for those who've plateaued on standard GLP-1 treatment or want steadier, more balanced support across appetite and blood sugar.

Your compound is prepared at a licensed 503A pharmacy, meaning it's made specifically for you under a valid prescription, and every batch is third-party tested for purity and potency before it reaches your door.

GLP-1 + GIP Semaglutide + Tirzepatide

Benefits

How the Combination Works

Semaglutide acts on the GLP-1 pathway, while tirzepatide acts on both GIP and GLP-1 pathways. Your prescribed plan determines how these medications are used as part of your overall weight-loss care.

More Complete Appetite Support

Semaglutide and tirzepatide work across GLP-1 and GIP pathways to help reduce hunger, quiet food noise, and make it easier to feel satisfied with less.

Stronger Metabolic Support

Together, semaglutide and tirzepatide support weight loss while helping regulate appetite, blood sugar, and insulin response.

Less Strain on the Body

As excess weight comes down, there may be less pressure on your joints and greater comfort in everyday movement.

Support for Heart Health

Improvements in weight and metabolic health may also benefit blood pressure, cholesterol, and other markers tied to cardiovascular health.

More Consistent Energy

Better blood sugar regulation and improved metabolic health may help support steadier energy and clearer focus throughout the day.

Your Ongoing Care

Your treatment is provider-guided from day one and adjusted as you go. You'll have a video visit every 90 days and metabolic lab testing every 6 months, so your provider can track your progress and fine-tune your dose based on your results and how you're feeling. Between visits, you have ongoing access to your care team for questions, side effect support, or dose changes, all with the same provider and the same standard of care at every step.

Shipping & Delivery

Your medication ships directly to your door every 4 weeks, with free shipping on every delivery. Because your compound needs to stay cold, it arrives in insulated, temperature-controlled packaging with ice packs to protect it in transit. Once it arrives, store it in the refrigerator as instructed by your provider. Each shipment comes ready to use, with your dose already set, so there's nothing extra to coordinate.

REAL STORIES REAL PROGRESS

See the remarkable journeys of our clients who achieved lasting weight loss and renewed confidence through personalized GLP-1 therapy.

Jennifer Cox

WEIGHT LOSS

-47 lbs

TIMEFRAME

6 months

Before

After

Michelle Eury

WEIGHT LOSS

-39 lbs

TIMEFRAME

4.5 months

Before

After

Kelli Huff

WEIGHT LOSS

-35 lbs

TIMEFRAME

4 months

Before

After

Lesly Martinez

WEIGHT LOSS

-51 lbs

TIMEFRAME

8 months

Before

After

Rebecca Southerland

WEIGHT LOSS

-48 lbs

TIMEFRAME

6 months

Before

After

PAY LESS. SAVE MORE.

PAY LESS FOR YOUR WEIGHT LOSS TREATMENT

Members pay provider pricing on their GLP-1 and every other medication in our catalog. Straightforward, transparent pricing and an average savings of 15% on medications alone. Most members cover the cost of their membership through medication savings alone. Everything else is just upside.

Join EverPrime

Aids in regulating glucose levels

Increases your daily energy levels

Slows digestion

Reduces appetite and control cravings

Aids in regulating glucose levels

Increases your daily energy levels

Slows digestion

Reduces appetite and control cravings

STAY ON TRACK

We track your progress over time on our platform every step of the way.

Unlike typical programs that only provide a lab report, your coach analyzes your results, integrates insights, and creates a data-driven plan aimed at achieving results. See your progress clearly, all in one place.

Start Intake

4 SIMPLE STEPS

TELL US ABOUT YOU

Share your health history, goals and what you have already tried.

Woman in blue scrubs writing on clipboard while using a laptop at a white desk.

MEET YOUR PROVIDER

A licensed provider reviews your information and helps determine the right path forward.

Closed cardboard box with the text ENHANCE.MD on the lid, placed on a textured surface with shadows.

START YOUR PLAN

If approved, your treatment is prescribed and delivered directly to your door.

Smiling older man holding a glass of drink and using a laptop at a table.

KEEP MOVING FORWARD

Your provider follows your progress and adjusts your care as your needs change.

TELL US ABOUT YOU

Share your health history, goals and what you have already tried.

MEET YOUR PROVIDER

A licensed provider reviews your information and helps determine the right path forward.

START YOUR PLAN

If approved, your treatment is prescribed and delivered directly to your door.

KEEP MOVING FORWARD

Your provider follows your progress and adjusts your care as your needs change.

HOW MUCH CAN YOU LOSE

20%

In a 72-week clinical study, adults taking tirzepatide lost an average of approximately 20% of their starting body weight.

Adults taking semaglutide lost an average of approximately 14% in the same head-to-head study.

Source: SURMOUNT-5 clinical trial, New England Journal of Medicine, 2025. Results reflect branded medications taken at maximum tolerated doses for 72 weeks. Our compounded medications use the same active ingredients but have not been studied in separate clinical trials, so results may differ. Individual results vary.

Select your current height

FEET

INCHES

Select your current weight 200lbs

Weight you could lose 40lbs

Based on average results from a 72-week clinical study using maximum tolerated doses alongside diet and exercise. Individual results vary.

Start Intake

Start your weight-loss for the last time

Up to 15% weight loss*

Join EverPrime

Start Intake

EXPERT LED TEAM

Professionals you can count on every step of the way

MEDICAL DIRECTOR

Dr. ERIK STARK

Medical Director

Dr. Erik Stark is a board-certified orthopedic and sports medicine surgeon with expertise in obesity and longevity medicine. A lifelong athlete and jiu-jitsu black belt, he combines clinical expertise with a performance-focused approach to helping patients stay strong, active, and healthy.

MEDICAL DIRECTOR

Dr. ERIK STARK

Medical Director

HAVE QUESTIONS?

What is a semaglutide/tirzepatide combo treatment plan?

A semaglutide/tirzepatide combo treatment plan incorporates both medications into the same treatment strategy. Semaglutide activates the GLP-1 receptor, while tirzepatide activates both GIP and GLP-1 receptors. These hormone pathways help regulate hunger, fullness, digestion, blood sugar, and insulin response. Using both medications allows the treatment plan to engage these pathways in a different way than either medication alone, which may be considered when a patient needs a more tailored approach based on their previous response to GLP-1 treatment.

Who may be eligible for this plan?

This plan may be considered for adults whose current or previous GLP-1 treatment is no longer providing the desired response, or who may benefit from a different treatment approach. Eligibility also depends on your health history, current medications, previous GLP-1 experience, pregnancy plans, and overall treatment goals. A licensed provider will review your information to determine whether the combination plan is appropriate for you.

How much weight can you lose with semaglutide/tirzepatide combo?

There is no established average for weight loss specifically with a semaglutide/tirzepatide combination plan. Results can vary based on your prescribed treatment, starting weight, previous response to GLP-1 medications, nutrition, activity, and how your body responds over time. Your provider will track your progress throughout treatment and evaluate how well the plan is working for you.

How long does a semaglutide/tirzepatide combo take to work?

Some people notice changes in hunger, cravings, portion size, or how quickly they feel full within the first few weeks of treatment. Changes on the scale usually build more gradually over the following months. Because this plan combines two medications that work on GLP-1 and GIP pathways, your provider will look closely at how your body responds over time, including both effectiveness and side effects. The first few weeks are often more about understanding your response to the treatment plan than judging your final results. Your provider will track your progress and make changes to your treatment plan when appropriate.

What are the possible side effects?

Both semaglutide and tirzepatide can cause digestive side effects, including nausea, diarrhea, vomiting, constipation, indigestion, and stomach discomfort. These effects may be more noticeable when treatment begins or if your prescribed plan changes. Side effects often improve as your body adjusts. Contact your provider if symptoms are persistent, getting worse, or making it difficult to eat, drink, or go about your normal activities. Seek prompt medical care for severe abdominal pain that does not go away, especially if it occurs with vomiting.

Does a semaglutide/tirzepatide combo cause muscle loss?

Weight loss with a semaglutide/tirzepatide combo can include some loss of lean muscle, just as it can with other weight-loss approaches. The goal is to lose more body fat while preserving as much muscle as possible. Eating enough protein and including regular resistance or strength training can help support muscle preservation, strength, and overall body composition during treatment.

Who should not use semaglutide or tirzepatide?

Semaglutide and tirzepatide should not be used by people with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2, or by anyone who has had a serious allergic reaction to either medication or its ingredients. Treatment is also not recommended during pregnancy. Your provider will review your health history, current medications, and any conditions that could affect treatment before determining whether a semaglutide/tirzepatide plan is appropriate for you.

ow is a semaglutide/tirzepatide combo different from taking either medication alone?

Semaglutide works on the GLP-1 receptor, while tirzepatide works on both GIP and GLP-1 receptors. A combination plan incorporates both medications into the same treatment strategy rather than relying on either medication alone. This gives your provider another way to tailor treatment based on your previous response, appetite changes, progress, and side effects.

Can this help if I’ve hit a plateau?

It may be considered if your progress has slowed after using semaglutide or tirzepatide alone. A plateau does not always mean your current medication has stopped working, so your provider will look at your overall response before deciding whether a different treatment approach makes sense. If appropriate, a combination plan may offer another option for supporting continued progress.

Can I switch from my current GLP-1 treatment?

Potentially. If you are currently taking semaglutide, tirzepatide, or another GLP-1 medication, your provider can review your current dose, how long you have been on treatment, your response, side effects, and overall health before recommending a change. Do not stop, combine, or switch GLP-1 medications on your own. Your provider will determine the appropriate transition plan for you.

THE OPTIMIZED LIFE, IN YOUR INBOX

What's new in peptides, longevity, and labs, plus member-only pricing.

Thank you! Your submission has been received!

Oops! Something went wrong while submitting the form.

By subscribing, you agree to our Terms & Conditions and Privacy Policy.

GLP-1 + GIP Semaglutide + Tirzepatide

How the Combination Works

More Complete Appetite Support

Stronger Metabolic Support

Less Strain on the Body

Support for Heart Health

More Consistent Energy

TRANSPARENT PRICING

REAL STORIES REAL PROGRESS

PAY LESS FOR YOUR WEIGHT LOSS TREATMENT

PAY LESS FOR YOUR WEIGHT LOSS TREATMENT

STAY ON TRACK

4 SIMPLE STEPS

Related Products

GLP-1 + GIP Tirzepatide